It is marketed with the registration number of SINP with effective from A glutamate antagonist receptors, glutamate used as an anticonvulsant anticonvulsants and to prolong the survival of patients with amyotrophic lateral sclerosis.A molecular dynamics simulation study of n
Riluzole is marketed as Rilutek by Sanofi. The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1 an inhibitory effect on glutamate release activation of glutamate reuptake2 inactivation of voltage-dependent sodium channels, and 3 ability to interfere with intracellular events that follow transmitter binding at excitatory amino acid receptors.
Riluzole is extensively metabolized to six major and a number of minor metabolites, which have not all been identified to date. Metabolism is mostly hepatic, consisting of cytochrome P—dependent hydroxylation and glucuronidation. Source of information: Drugbank External Link.
Last updated on: 3 rd July Although best effort has been made to ensure the information provided is correct and updated, users are advised to visit HSA Official website whenever in doubt. Please see Disclaimers. Please contact us Text Us! About Pharmfair. Approval Information. Description A glutamate antagonist receptors, glutamate used as an anticonvulsant anticonvulsants and to prolong the survival of patients with amyotrophic lateral sclerosis.
Mechanism of Action The mode of action of riluzole is unknown. Distribution Metabolism Riluzole is extensively metabolized to six major and a number of minor metabolites, which have not all been identified to date.This medication available in the form of tablet to take by mouth, twice a day, every 12 hours.
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The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer. This site complies with the HONcode standard for trustworthy health information: verify here. Rilutor 50mg Riluzole Drug Price and Information Rilutor 50mg is a benzothiazole, recommended for amyotrophic lateral sclerosis ALS, Lou Gehrig disease is placed on a ventilator or breathing machine, by delaying onset of ventilator dependence or tracheostomy.
It may prevent further damage to certain brain cells. Medindia Drugs Drug Price. Medindia currently has information on generic drugs andbrands that have their prices listed. New drugs with their prices are listed as and when they get approved by the drug controller. Please do write to us info medindia.
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Pharma Links. Medindia Newsletters. Subscribe to our Free Newsletters! Follow Us On :.Generic Name: riluzole Dosage Form: tablet. Medically reviewed by Drugs. Last updated on Jun 21, The recommended dosage for Rilutek is 50 mg taken orally twice daily.Amyotrophic Lateral Sclerosis (ALS)
Rilutek should be taken at least 1 hour before or 2 hours after a meal [see Clinical Pharmacology Measure serum aminotransferases before and during treatment with Rilutek [see Warnings and Precautions 5. Rilutek is contraindicated in patients with a history of severe hypersensitivity reactions to riluzole or to any of its components anaphylaxis has occurred [see Adverse Reactions 6. Cases of drug-induced liver injury, some of which were fatal, have been reported in patients taking Rilutek.
Asymptomatic elevations of hepatic transaminases have also been reported, and in some patients have recurred upon rechallenge with Rilutek. In clinical studies, the incidence of elevations in hepatic transaminases was greater in Rilutek-treated patients than placebo-treated patients.
Maximum increases in ALT occurred within 3 months after starting Rilutek. Monitor patients for signs and symptoms of hepatic injury, every month for the first 3 months of treatment, and periodically thereafter.
The use of Rilutek is not recommended if patients develop hepatic transaminase levels greater than 5 times the ULN. Discontinue Rilutek if there is evidence of liver dysfunction e. Cases of severe neutropenia absolute neutrophil count less than per mm 3 within the first 2 months of Rilutek treatment have been reported.
Advise patients to report febrile illnesses. Interstitial lung disease, including hypersensitivity pneumonitis, has occurred in patients taking Rilutek. Discontinue Rilutek immediately if interstitial lung disease develops. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In the placebo-controlled clinical trials in patients with ALS Study 1 and 2a total of patients received Rilutek 50 mg twice daily [see Clinical Studies 14 ]. The most common adverse reactions leading to discontinuation in the Rilutek group were nausea, abdominal pain, constipation, and elevated ALT. There was no difference in rates of adverse reactions leading to discontinuation in females and males. The adverse reaction profile was similar in older and younger patients.
There were insufficient data to determine if there were differences in the adverse reaction profile in different races.Medically reviewed by Drugs. Rilutek is not a cure for ALS, but it may delay progression of the disease and prolong your life. Follow all directions on your medicine label and package.
Tell each of your healthcare providers about all your medical conditions, allergiesand all medicines you use. Rilutek may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Rilutek 50 Mg Tablet, Packaging Type: Box
Shake the oral suspension liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. Store at room temperature away from moisture, heat, and light. Keep the liquid medicine upright and do not freeze. Throw away any unused liquid after 15 days. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not take two doses at one time. Overdose symptoms may include drowsiness, confusion, problems with thinking or memory, coma, tremors, or blue lips or fingers. Avoid smoking. Smoking cigarettes may make Rilutek less effective. Get emergency medical help if you have signs of an allergic reaction: hives ; difficult breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Rilutek side effects in more detail. Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Rilutek can harm your liver, especially if you also use certain medicines for infections, high cholesterolseizuresbirth control, hormone replacement, or pain or arthritis including TylenolAdviland Aleve.
Other drugs may affect Rilutek, including prescription and over-the-counter medicines, vitaminsand herbal products.
RILUTEK TABLET 50mg
Tell your doctor about all your current medicines and any medicine you start or stop using. Rilutek drug interactions in more detail. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Taj Distributors is an entity that is aspires towards covering the entire global market by its best and optimum medicinal products.
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Ask for more details from the seller Contact Seller. Product Details. Riluzole helps to slow down the worsening of this disease and prolong survival. Do not increase your dose or take this drug more Interested in this product?
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RILUTEK is contraindicated in patients with a history of severe hypersensitivity reactions to riluzole or to any of its components anaphylaxis has occurred [see Adverse Reactions 6. Asymptomatic elevations of hepatic transaminases have also been reported, and in some patients have recurred upon rechallenge with RILUTEK. In clinical studies, the incidence of elevations in hepatic transaminases was greater in RILUTEK-treated patients than placebo-treated patients.
Monitor patients for signs and symptoms of hepatic injury, every month for the first 3 months of treatment, and periodically thereafter. Cases of severe neutropenia absolute neutrophil count less than per mm 3 within the first 2 months of RILUTEK treatment have been reported.
Advise patients to report febrile illnesses. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
There was no difference in rates of adverse reactions leading to discontinuation in females and males.
The adverse reaction profile was similar in older and younger patients. There were insufficient data to determine if there were differences in the adverse reaction profile in different races. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The concomitant use of strong or moderate CYP1A2 inhibitors e.
Lower exposures may result in decreased efficacy [see Clinical Pharmacology Clinical trials in ALS patients excluded patients on concomitant medications which were potentially hepatotoxic e. The background risk for major birth defects and miscarriage in patients with amyotrophic lateral sclerosis is unknown. In the U. Maternal toxicity was observed at the highest dose tested in rat and rabbit. It is not known if riluzole is excreted in human milk.
Riluzole or its metabolites have been detected in milk of lactating rats. Women should be advised that many drugs are excreted in human milk and that the potential for serious adverse reactions in nursing infants from RILUTEK is unknown. In rats, oral administration of riluzole resulted in decreased fertility indices and increases in embryolethality [see Nonclinical Toxicology No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Thus, patients with mild or moderate hepatic impairment may be at increased risk of adverse reactions.
The impact of severe hepatic impairment on riluzole exposure is unknown. Use of RILUTEK is not recommended in patients with baseline elevations of serum aminotransferases greater than 5 times upper limit of normal or evidence of liver dysfunction e. Japanese patients are more likely to have higher riluzole concentrations. Consequently, the risk of adverse reactions may be greater in Japanese patients [see Clinical Pharmacology For current information on the management of poisoning or overdosage, contact the National Poison Control Center at or www.
The chemical designation for riluzole is 2-amino trifluoromethoxy benzothiazole. The chemical structure is:.Zf gearbox splitter problems
RILUTEK is a white to slightly yellow powder that is very soluble in dimethylformamide, dimethylsulfoxide, and methanol; freely soluble in dichloromethane; sparingly soluble in 0. Each film-coated tablet for oral use contains 50 mg of riluzole and the following inactive ingredients: anhydrous dibasic calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, and titanium dioxide.
The mechanism by which riluzole exerts its therapeutic effects in patients with ALS is unknown.However, filling a Rilutek prescription without coverage can force Americans to make difficult decisions about their care. Learn more about Prescription Hope, our process, and apply today to receive Rilutek.
This medication is not a cure for ALS. Those who are prescribed Rilutek by their doctors may be able to obtain their medicine through Prescription Hope for an affordable price. When an application is sent to Prescription Hope, our team immediately begins working to manage, track and refill medications on time, maintain up-to-date records, and renew prescription medications every year. After an individual is approved, the first shipment of their prescription medication typically arrives within four to six weeks, with refills coming on a regular schedule.
Through our program, Americans have saved millions off the retail cost of their prescription medications. Prescription Hope is not a discount card or insurance policy.
Rather, Prescription Hope is a national pharmacy program that works with any coverage you may already have. As a complimentary program, we work to fill gaps that other coverage, including discount drug cards, may leave behind. If Prescription Hope cannot help an individual obtain a medication, we will not charge a fee for that medication.
Our highly dedicated team works directly with over U. Prescription Hope can even obtain the top prescribed medications in the United States. Apply for Prescription Hope today, and start receiving your prescription medication at an affordable price. Because we are not an insurance product, our national advocacy program works outside of prescription medication tiers.
Some of the biggest insurance organizations across the United States trust Prescription Hope, referring individuals to us for their prescription medications.
When adding Prescription Hope, insurance organizations can keep customers through another avenue of care. Contact us today, and learn more about how Prescription Hope can help individuals obtain affordable prescription medication. Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website.
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